Links, Curiosities & Mixed Wonders – 18

Me, preparing this post.

Welcome to the column which — according to readers — is responsible for many wasted worktime hours, but also provides some fresh conversation starters.

Allow me the usual quick summary of what happened to me over the last few weeks: in addition to being on the radio, first as a guest at Miracolo Italiano on RaiRadio2, and then interviewed on Radio Cusano Campus, a couple of days ago I was invited to take part in a broadcast I love very much, Terza Pagina, hosted by astrophysicist and fantasy author Licia Troisi. We talked about the dark meaning of the carnival, the upcoming TV series adapted from Umberto Eco’s The Name of the Rose, a rather weird scientific research, and one book that is particularly close to my heart. The episode is available for streaming on RaiPlay (but of course it’s in Italian only).

Let’s start with some wonderful links that, despite these pleasant distractions, I have collected for you.

Do you remember my article on coffin births, i.e. those cases in which the fetus is expelled post-mortem from the body of the mother? Well, apparently 180 million years ago ichthyosaurs had coffin births too.

Every week for forty years a letter written by a Japanese gentleman, Mr. Kaor, was delivered to Hotel Spaander in Holland. The handwritten message was always the same: “Dear Sirs, how are you and how is the weather this week?”. Finally in 2018 some journalists tracked down the mysterious sender, discovering that 1) he had never set foot in that Dutch hotel in his entire life, and 2) some rather eccentric motivations were behind those 40 years of missives. Today Mr. Kaor even has his own portrait inside the hotel. Here is the full story. (Thanks, Matthew!)
Ever heard of the Holocene Extinction, the sixth mass extinction ever occurred on our planet?
You should, because it’s happening now, and we’ve caused it.
As for me, perhaps because of all the semiotics I studied at the university, I am intrigued by its linguistic implications: the current situation is so alarming that scientists, in their papers, are no longer using that classic, cold, distant vocabulary. Formal language does not apply to the Apocalypse.
For example, a new research on the rapid decline in the population of insects on a global scale uses surprisingly strong tones, which the authors motivate as follows: “We wanted to really wake people up. When you consider 80% of biomass of insects has disappeared in 25-30 years, it is a big concern. […] It is very rapid. In 10 years you will have a quarter less, in 50 years only half left and in 100 years you will have none.“
On a more optimistic note, starting from the second half of this year new emojis will arrive on our smartphones, specifically dedicated to disability and diversity. And yes, they will also include that long-awaited emoticon for menstruation.
Although he had proclaimed himself innocent, Hew Draper was imprisoned in the Tower of London for witchcraft. Once in his cell, he began sculpting this stuff on the wall. Suuuure, of course you’re innocent, Mr. Draper.

Here’s a nice article (Italian only) on death & grief in the digital era, mentioning Capsula Mundi, the Order of the Good Death, as well as myself.
Thomas Morris’ blog is always one of my favorite readings. This gentleman tirelessly combs through 19th-century medical publications in search of funny, uplifting little stories — like this one about a man crushed by a cartwheel which pushed his penis inside his abdomen, leaving its full skin dangling out like an empty glove.
There is one dramatic and excruciating picture I can not watch without being moved. It was taken by freelance photographer Taslima Akhter during the rescue of victims of the terrible 2013 Rana Plaza building collapse in Bangladesh (which took the life of 1129 people, and wounded more than 2500). The photo, entitled Final Embrace, has won numerous awards and you can see it by clicking here.
Jack Stauber is a brilliant madman: he produces nonsense music videos that seem salvaged from some 1980s VHS, and are among the most genuinely creepy and hilarious things you’ll see on YouTube. Below I prresent you with the wonderful Cooking with Abigail, but there’s plenty more on his channel.

A new book on Jack The Ripper has been released in the UK.
“Another one?”, I hear you say.
Yes, but this is the first one that’s all about the victims. Women whose lives no scholar has ever really been interested in because, you know, after all they were just hookers.
Let’s say you’re merrily jumping around, chasing butterflies with your little hand net, and you stumble upon a body. What can you do?
Here’s a useful infographic:

The latest issue of Godfrey’s Almanack explores folklore and magic in the West Indies.
Speaking of folklore, the original Sirens were not half-woman, half-fish creatures; they were more like ugly pest birds with a human head.
Most important physics question: how many times do you need to slap a chicken to cook it? (via Pietro Minto)
Most important chemistry question: why do books smell so good?

Above are some works by Lidia Kostanek, a Polish artist who lives in Nantes, whose ceramic sculptures investigate the body and the female condition. (via La Lune Mauve)
On this blog I have addressed the topic of head transplants several times. Still I did not know that these transplants have been successfully performed for 90 years, keeping both the donor and the recipient alive. Welcome to the magical world of insect head transplants. (Thanks, Simone!)

You all know about canaries in the mine. In spite of the cruelty (by modern standards) of this practice, miners often became attached to these canaries, to which they owed their lives: a testimony of this affection is the device pictured below, which was used to resuscitate the poor little birds.

Last but not least, a documentary film I personally have been waiting for a while is finally opening in Italian cinemas: it’s called Wunderkammer – Le Stanze della Meraviglia, and it will disclose the doors of some of the most exclusive and sumptuous wunderkammern in the world. Among the collectors interviewed in the film there’s also a couple of friends, including the one and only Luca Cableri whom you may have seen in the Bizzarro Bazar Web Series. Here’s the movie trailer, and if you happen to be in Italy on March 4th, 5th and 6th, here’s a list of theatres that screen the film.

The Homunculus Inside

Jan27

Paracelsus‘ homunculus, the result of complicated alchemic recipes, is an allegorical figure that fascinated the collective uncoscious for centuries. Its fortune soon surpassed the field of alchemy, and the homunculus was borrowed by literature (Goethe, to quote but one example), psychology (Jung wrote about it), cinema (take the wonderful, ironic Pretorius scene from The Bride of Frankenstein, 1935), and the world of illustration (I’m thinking in particular of Stefano Bessoni). Even today the homunculus hasn’t lost its appeal: the mysterious videos posted by a Russian youtuber, purportedly showing some strange creatures developed through unlikely procedures, scored tens of millions of views.

Yet I will not focus here on the classic, more or less metaphorical homunculus, but rather on the way the word is used in pathology.
Yes beacuse, unbeknownst to you, a rough human figure could be hiding inside your own body.
Welcome to a territory where the grotesque bursts into anatomy.

Let’s take a step back to how life starts.
In the beginning, the fertilized cell (zygote) is but one cell; it immediately starts dividing, generating new cells, which in turn proliferate, transform, migrate. After roughly two weeks, the different cellular populations organize into three main areas (germ layers), each one with its given purpose — every layer is in charge of the formation of a specific kind of structure. These three specialized layers gradually create the various anatomical shapes, building the skin, nerves, bones, organs, apparatuses, and so on. This metamorphosis, this progressive “surfacing” of order ends when the fetus is completely developed.

Sometimes it might happen that this very process, for some reason, gets activated again in adulthood.
It is as if some cells, falling for an unfathomable hallucination, believed they still are at an embryonic stage: therefore they begin weaving new structures, abnormal growths called teratomas, which closely resemble the outcome of the first germ differentiations.

These mad cells start producing hair, bones, teeth, nails, sometimes cerebral or tyroid matter, even whole eyes. Hystologically these tumors, benign in most cases, can appear solid, wrapped inside cystes, or both.

In very rare cases, a teratoma can be so highly differentiated as to take on an antropomorphic shape, albeit rudimentary. These are the so-called fetiform teratomas (homunculus).

Clinical reports of this anomaly really have an uncanny, David Cronenberg quality: one homunculus found in 2003 inside an ovarian teratoma in a 25-year-old virginal woman, showed the presence of brain, spinal chord, ears, teeth, tyroid gland, bone, intestines, trachea, phallic tissue and one eye in the middle of the forehead.
In 2005 another fetiform mass had hairs and arm buds, with fingers and nails. In 2006 a reported homunculus displayed one upper limb and two lower limbs complete with feet and toes. In 2010 another mass presented a foot with fused toes, hair, bones and marrow. In 2015 a 13-year-old patient was found to carry a fetiform teratoma exhibiting hair, vestigial limbs, a rudimentary digestive tube and a cranial formation containing meninxes and neural tissue.

What causes these cells to try and create a new, impossible life? And are we sure that the minuscule, incomplete fetus wasn’t really there from the beginning?
Among the many proposed hypothesis, in fact, there is also the idea that homunculi (difficult to study because of their scarcity in scientific literature) may not be actual tumors, but actually the remnants of a parasitic twin, incapsulated within his sibling’s body during the embryonic phase. If this was the case, they would not qualify as teratomas, falling into the fetus in fetu category.

But the two phenomenons are mainly regarded as separate.
To distinguish one from the other, pathologists rely on the existence of a spinal column (which is present in the fetus in fetu but not in teratomas), on their localization (teratomas are chiefly found near the reproductive area, the fetus in fetu within the retroperitoneal space) and on zygosity (teratomas are often differentiated from the surrounding tissues, as if they were “fraternal twins” in regard to their host, while the fetus in fetu is homozygote).

The study of these anomalous formations might provide valuable information for the understanding of human development and parthenogenesis (essential for the research on stem cells).
But the intriguing aspect is exactly their problematic nature. As I said, each time doctors encounter a homunculus, the issue is always how to categorize it: is it a teratoma or a parasitic twin? A structure that “emerged” later, or a shape which was there from the start?

It is interesting to note that this very uncertainty also has existed in regard to normal embryos for the over 23 centuries. The debate focused on a similar question: do fetuses arise from scratch, or are they preexistent?
This is the ancient dispute between the supporters of epigenesis and preformationism, between those who claimed that embryonic structures formed out of indistinct matter, and those who thought that they were already included in the egg.
Aristotle, while studying chicken embryos, had already speculated that the unborn child’s physical structures acquire solidity little by little, guided by the soul; in the XVIII Century this theory was disputed by preformationism. According to the enthusiasts of this hypothesis (endorsed by high-profile scholars such as Leibniz, Spallanzani and Diderot), the embryo was already perfectly formed inside the egg, ab ovo, only too small to be visible to the naked eye; during development, it would just have to grow in size, as a baby does after birth.
Where did this idea come from? An important part was surely played by a well-known etching by Nicolaas Hartsoeker, who was among the first scientists to observe seminal fluid under the microscope, as well as being a staunch supporter of the existence of minuscule, completely formed fetuses hiding inside the heads of sperm cells.
And Hartsoeker, in turn, had taken inspiration precisely from the famous alchemical depictions of the homunculus.

In a sense, the homunculus appearing in an ancient alchemist’s vial and the ones studied by pathologists nowadays are not that different. They can both be seen as symbols of the enigma of development, of the fundamental mystery surrounding birth and life. Miniature images of the ontological dilemma which has been forever puzzling humanity: do we appear from indistinct chaos, or did our heart and soul exist somewhere, somehow, before we were born?

Little addendum of anatomical pathology (and a bit of genetics)
by Claudia Manini, MD